研究成果

AI-Augmented Iterative Screening of Libraries Against RNA Targets (AISLAR) Boosts Discovery of SAR-Tractable RNA Binders and Rational Analog Design

Hattori H, Otsu M, Imai K, Narahara M, Kondo J, Shino A, Morishita EC, Small Science, April 17, 2026

Recent applications of artificial intelligence in RNA-targeted small molecule drug discovery

Morishita EC, Nakamura S, Expert Opinion on Drug Discovery, Apr 2024

Probing RNA-Small Molecule Interactions Using Biophysical and Computational Approaches

Shino A, Otsu M, Imai K, Fukuzawa K, Morishita EC, ACS Chem Biol., Nov 17, 2023

Discovery of RNA-targeted small molecules through the merging of experimental and computational technologies

Morishita EC, Expert Opinion on Drug Discovery, Feb 2023

Interaction between a fluoroquinolone derivative and RNAs with a single bulge
Nagano K, Kamimura T, Kawai G, J Biochem., Feb 21, 2022

Developing an Updated Strategy for Estimating the Free-Energy Parameters in RNA Duplexes

Dawson WK, Shino A, Kawai G, Morishita EC, Int J Mol Sci., Sep 8, 2021

Visualizing RNA Structure & Linking It to Function to More Reliably Discover Functional Binders

Morishita EC, 8th Annual RNA-Targeted Drug Discovery & Development Summit (Workshop talk), Boston, MA, USA, Dec 2, 2025 (Invited)

(Poster) 11th Novalix Conference

Shino A, 11th Novalix Conference (Poster), Strasbourg, France, May 21, 2025

Using AI for mRNA-Targeted Small Molecule Drug Discovery: Tips, Tricks, and Pitfalls
Morishita EC, 20th Annual Drug Discovery Chemistry (Invited talk), San Diego, CA, USA, Apr 15, 2025

Uncovering Hidden Druggable Targets on Your RNAs of Interest Using In-Silico Technologies
Morishita EC, RNA Assay Development & Screening Summit, Boston, MA, USA, Aug 24, 2023

Paving the Way for the Discovery of Small-Molecule Drugs Targeting the mRNA
Morishita EC, Drug Discovery Chemistry VIRTUAL, Aug 25–28, 2020

Design of high-affinity RNA binders using an FMO-calculation-based DMTA cycle
Imai K, The 42nd Medicinal Chemistry Symposium (Short oral & poster), Tokushima, Japan, Nov 18, 2025

Convergence of Machine Learning and High-Quality Biophysical Techniques Boosts Discovery of SAR-Tractable RNA Ligands and Rational Analogue Design
Hattori H, ISNAC2025 (Oral), Toyama, Japan, Nov 12, 2025

Convergence of Machine Learning and High-Quality Biophysical Techniques Boosts Discovery of SAR-Tractable RNA Ligands and Rational Analogue Design
Hattori H, CBI Society Annual Meeting 2025, Tokyo, Japan, Oct 30, 2025

Introduction to Veritas In Silico, the emerging biotech focusing on mRNA
Nakamura S, The Chemical Society of Japan, 105th Spring Annual Meeting, Kansai University, Japan, Mar 28, 2025

Small molecule drug discovery targeting mRNA -Toward the creation of small molecule drugs that selectively bind to RNA structures
Nakamura S, The 41st Medicinal Chemistry Symposium, Kyoto, Japan, Nov 21, 2024

Exploration of RNA-Targeted Small Molecule Compounds for Drug Discovery
Otsu M, The 41st Medicinal Chemistry Symposium (Short oral & poster), Kyoto, Japan, Nov 21, 2024

Unveiling the Potential of RNA-Targeted Small Molecule Therapies: Innovations in Computational and Biophysical Approaches
Morishita EC, CBI Society Annual Meeting 2024, Tokyo, Japan, Oct 29, 2024

RNA-targeted small-molecule drug discovery: screening and interaction analysis
Shino A, The 37th Medicinal Chemistry Symposium, Tokyo, Japan, Nov 27–29, 2019

Venturing into the untapped: Discovery of small-molecule drugs targeting Messenger RNAs using biophysical and computational methods
Morishita EC, The 7th NovAliX Conference on Biophysics in Drug Discovery, Kyoto, Japan, Nov 13–15, 2019